Zeighami Y, et al. - Researchers examined whether Parkinson disease (PD) prognosis could be predicted via an atrophy pattern from whole-brain structural MRI, measured in the drug-naïve early stage. From the Parkinson Progression Markers Initiative dataset, they examined MRI scans from 362 PD patients and half as many age-matched controls. Follow-up of patients was done for 4-5 years. Findings suggested a single MRI-derived structural atrophy measure as valuable as an early biomarker for PD prognosis. In this PD-network atrophy measure, atrophy in midbrain, basal ganglia, basal forebrain, medial temporal lobe, and discrete cortical regions were combined into a single score for each patient. This score was identified as predictive of progression of motor impairment, clinical severity phenotype, cognition and a global measure of PD severity. After regressing out the effect of age, these results remained significant and in a validation analysis in an independent sample was done, these results were validated.