Bailey LC, Razzaghi H, Burrows EK, et al. - In this cohort study using electronic health records for 135,794 US pediatric patients (53% male; mean [SD] age, 8.8 [6.7] years; 3% Asian patients, 15% Black patients, 11% Hispanic patients, and 59% White patients; 290 per 10,000 population [range, 155-395 per 10,000 population across health systems]) in 7 children’s health systems, researchers sought to describe testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the epidemiology of infected patients. SARS-CoV-2 infection rates were low in this large cohort study of US pediatric patients, and clinical manifestations were typically mild. Black, Hispanic, and Asian race/ethnicity; adolescence and young adulthood; and nonrespiratory chronic medical conditions were linked to identified infection. Diagnosing Kawasaki's disease is not an appropriate proxy for childhood multisystem inflammatory syndrome.