Luo Q, Wen Z, Li Y, et al. - Two-sample bidirectional Mendelian randomization (MR) analyses and various sensitivity analyses were conducted to evaluate whether the relationships between serum UA levels and schizophrenia are causal and to determine the direction of the correlation. This analysis was carried out to utilize the summary data from genome-wide association studies within the Global Urate Genetics Consortium and the Psychiatric Genomics Consortium. In this study, secondary MR analyses in both directions were performed within summary data utilizing genetic risk scores (GRSs) as instrumental variables. Whereas the causal role of serum UA concentrations in schizophrenia was not helped by the MR analyses, schizophrenia may causally influence serum UA levels. The data implies that UA may be a beneficial potential biomarker for monitoring treatment or diagnosis of schizophrenia rather than a therapeutic target for schizophrenia.