Wang AM, et al. - Researchers investigated if localized magnetic resonance spectroscopy (MRS) performed at 7-T can perceive metabolic changes early in the course of a first-episode psychosis. In addition, they examined if these are linked with neuropsychological performance. The comparison was done between 81 patients with first-episode psychosis and 91 age-matched control participants. N-acetylaspartate levels were decreased in numerous brain regions, in addition to a decrease in glutamate, glutathione and γ-aminobutyric acid in selective regions. The findings support the utility of 7-T MRS for detecting multiple metabolic abnormalities in patients with first-episode psychosis, which correlated with performance on neuropsychological tests.