Larivée N, et al. - Because aspirin-exacerbated respiratory disease (AERD) is an aggressive form of chronic rhinosinusitis with nasal polyposis that is notoriously difficult to treat and there is evidence to suggest desensitization to aspirin may improve symptomatology and disease control in these patients, researchers sought to critically assess the literature on this topic and evaluate the impact of desensitization on sinonasal symptomatology. EMBASE, CINAHL, MEDLINE, and the Cochrane Library for relevant literature were searched. Twenty-four studies had met the criteria for inclusion. Overall, polyp size, polyp recurrence, nasal symptom scores, sense of smell, number of acute episodes of rhinosinusitis, and systemic use of steroids improved when desensitized patients. The vast majority of investigations suggest desensitization. There is mounting evidence that in the treatment of patients with AERD, aspirin desensitization is a valuable adjunct to treat sinonasal symptoms.