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Aspirin and the risk of non‐digestive tract cancers: An updated meta‐analysis to 2019

International Journal of Cancer Oct 02, 2020

Santucci C, Gallus S, Martinetti M, et al. - This systematic review and meta‐analysis was performed to offer an up‐to‐date assessment of the risk of lung, breast, endometrium, ovary, prostate, bladder, and kidney cancer in correlation with aspirin use. Researchers analyzed all observational studies published up to March 2019. They considered overall 148 studies. A decreased risk of lung, breast, endometrial, ovarian, and prostate cancer, was observed in relation to regular aspirin use. However, in cohort and nested case‐control studies, risk reductions for most cancers were not significant, and between‐study heterogeneity was present. Overall, the findings corroborated that regular aspirin use has no appreciable impact on cancers of the bladder and kidney. In addition, small and heterogeneous inverse links were quantified for other neoplasms considered.

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