Gillis K, et al. - This current investigation for the impact of ascorbic acid on oxidative stress and vascular function in chronic kidney disease (CKD) patients compared with controls with hypertension (HTN) demonstrated pro- and antioxidant effects of ascorbic acid, resulting in an attenuation in central blood pressure and augmentation index in HTN and CKD. Moreover, via attenuating serum asymmetric dimethylarginine (ADMA) in CKD, ascorbic acid may offer longer-term benefits.