Chalmers JR, Haines RH, Bradshaw LE, et al. - In this multicentre, pragmatic, parallel-group, randomised controlled trial, researchers ascertained if daily use of emollient in the first year could prevent eczema in high-risk children. This investigation was conducted in 12 hospitals and four primary care sites across the UK. For this investigation, term newborns with a family history of atopic disease have been randomly assigned (1:1) to application of emollient daily (either Diprobase cream or DoubleBase gel) for the first year plus standard skin-care advice (emollient group) or standard skin-care advice only (control group). One thousand three hundred ninety-four newborns [693 were assigned to the emollient group and 701 to the control group] were randomly assigned to study groups between November 19, 2014, and November 18, 2016. No evidence has been found that daily emollients in the first year of life prevent eczema in high-risk children and some evidence indicates an increased risk of skin infections. The research indicates that families with eczema, asthma, or allergic rhinitis do not use daily emollients in their newborn to try and prevent eczema.