Chan CK, Yang WS, Lin YH, et al. - In this retrospective observational cohort study, experts aspired to explore whether arterial stiffness estimated by brachial-ankle pulse wave velocity before adrenalectomy was correlated with the clinical outcomes and cardiorenal injury in lateralized primary aldosteronism (PA) patients after adrenalectomy. Lateralized PA patients undergoing adrenalectomy were collected from the Taiwan Primary Aldosteronism Investigation database between 2013 and 2016. The sample consisted of 221 patients with lateralized PA (50.7% men; mean age, 51.9 years), of which 101 patients (45.7%) achieved complete clinical success at 1-year follow-up after adrenalectomy. Findings suggested that the preoperative severe arterial stiffness has been linked to absent complete clinical success in lateralized PA patients after adrenalectomy, and this impact can contribute to cardiorenal injury, which at least partially explains the deterioration of kidney function and decreased regression of heart mass.