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Arterial lactate concentration at the end of liver transplantation is an early predictor of primary graft dysfunction

Annals of Surgery Jun 17, 2019

Golse N, et al. - Researchers evaluated the reliability of performing the intraoperative assay of arterial lactate concentration at the end of liver transplantation (LCEOT) in predicting early outcomes [primary nonfunction, early graft dysfunction]. Analysis of data from a prospective database in a single center concerning patients transplanted revealed that the training (year 2015) and validation groups (year 2016) had no statistical imbalance for epidemiological and perioperative feature. The assay of arterial LCEOT ≥5 mmol/L reflects both hypoperfusion and tissue damage. It seems to be a strong predictor of early graft outcomes and may have utility as an endpoint in studies assessing the impact of perioperative management. Considering its accessibility and low cost, it seems to be a reliable parameter to predict postoperative management and assist clinicians in decision-making in the first postoperative day.
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