Do EK, Rossi B, Miller CA, et al. - With the aim to determine the variation in human papillomavirus (HPV) vaccination coverage by geography, researchers conducted a systematic review of the literature on Medline and Embase databases using a combination of keywords (HPV vaccination, geography, neighborhoods, and sociodemographic factors). Among 733 identified records, inclusion criteria were met by 25 for systematic review. The studies reported an average initiation rate of 40.5% (range, 6.3%–78.0%) and an average rate of completion of 23.4% (range, 1.7%–55.2%). HPV vaccination was observed to be correlated with geographic regions and area-level factors, including zip code tabulation area-level poverty, urbanicity/rurality, racial/ethnic composition, and health service region features. Results here establish the necessity to move toward adoption of geospatial approaches that help map and identify geographic areas with low rates of HPV vaccination.