Womack JA, Murphy TE, Ramsey C, et al. - Findings demonstrated that serious falls within the past year were strongly related to fragility fractures in persons living with HIV (PWH) receiving antiretroviral therapy (ART)—largely a middle-aged population—much as they are in older adults in the general population.

• A total of 26,373 PWH (50+ years of age) and on ART were analyzed in the Veterans Aging Cohort Study.

• Serious falls were defined as those falls significant enough to lead to a visit to a health care provider.

• Post-adjustment, an elevated risk of fragility fracture [odds ratio (OR) 2.10] was noted in relation to serious falls in the previous year.

• The only ART risk factor was use of integrase inhibitors (OR 1.17).

• Diagnosis of alcohol use disorder (OR 1.49) and having a prescription for an opioid in the previous 6 months (OR 1.40) were found to be other risk factors.