Kanbayti IH, et al. - Researchers examined how baseline mammographic density (BMD), and mammographic density (MD) reduction (MDR) following breast cancer (BC) treatment are associated with patient outcomes. They used the PRISMA strategy to extract relevant details from relevant articles that were identified from six databases (CINAHL, Scopus, PubMed, Web of Science, MEDLINE, and Embase). The analysis revealed an association of BMD with contralateral breast cancer (CBC) risk (HR = 1.9), recurrence (HR = 2.0), and mortality (HR = 1.4). Evidence suggested an association of MDR with a reduced risk of recurrence, however, there were limited data on the influence of MDR on outcomes such as mortality, and CBC risk. Evidence, although sparse, illustrates the association of high BMD with an increased risk of recurrence, CBC, and mortality. Conversely, reduced risk of BC recurrence, CBC, and BC-related mortality was observed in correlation with MDR.