Kahraman R, et al. - The adiponectin and leptin levels and insulin resistance (IR) in patients with inflammatory bowel disease (IBD) and the relationship between these factors and IBD characteristics were scrutinized in this study. It was demonstrated that leptin levels increased and adiponectin levels reduced in patients with IBD, which is thought to be associated with chronic inflammation. The impacts of adipocytokines in patients with IBD with inflammatory and metabolic processes should be researched in further broader studies.

• Fasting serum leptin, adiponectin, glucose, and insulin levels, and additionally to inflammatory parameters, were measured in 105 patients with IBD (49 patients with Crohn's disease [CD], 56 patients with ulcerative colitis [UC]) and 98 healthy controls [HC].
• IR was assessed utilizing the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR).
• Disease activity and severity in patients with UC were assessed utilizing the Truelove–Witts index, and patients with CD were evaluated using the Crohn's Disease Activity Index.
• Serum adiponectin levels were observed to be significantly lower in patients with CD and UC (p<0.001).
• Serum leptin levels were also observed to be significantly higher in both the UC and CD groups (p<0.001).
• When HOMA-IR levels were compared, no significant difference was detected for either the CD or UC groups compared with the controls.