Yang KB, Sun XY, Sun LP, et al. - In the present study, the researchers sought to examine the impact of intravitreal conbercept (IVC) injections on the aqueous humor concentrations of angiogenic and inflammatory cytokines in patients with macular edema (ME) due to central retinal vein occlusion and to ascertain if changes in cytokine levels after IVC are correlated with the development of rebound ME. Forty-nine patients with ME caused by central retinal vein occlusion were involved. According to this retrospective study, in patients with ME caused by central retinal vein occlusion, angiogenic and inflammatory cytokines were overexpressed. Conbercept treatment decreased aqueous vascular endothelial growth factor and placental growth factor concentrations and affected the concentrations of various inflammatory cytokines. After antivascular endothelial growth factor therapy, rebound ME may occur due to a disruption in the balance between angiogenic and inflammatory cytokines, as well as an ensuing excess of inflammatory but not angiogenic cytokines.