de Morais LC, et al. - In high-risk patients scheduled for laparoscopic procedures to treat abdominal or pelvic cancer, the efficacy of aprepitant in reducing the incidence of post-operative nausea and vomiting (PONV) was determined when administered as an addition to a multimodal regimen. The control group received oral starch and the treatment group received 80 mg of oral aprepitant before induction of anaesthesia. In the first 24 h after anaesthesia, vomiting occurred in 13/32 (40.6%) patients in the control group, whereas, in 1/34 (2.9%) patients in the treatment group. Overall, 80 mg of added to a three-drug multimodal prophylaxis strategy can reduce PONV episodes and rescue antiemetic requirements in a high-risk population.