Wei H, et al. - Researchers analyzed the levels of serum biomarkers in moderate-Alzheimer’s disease (AD) patients the value of these serum biomarkers for the diagnosis of memantine sensitivity in AD patients who are significantly affected by MEM. For this investigation, 177 subjects with moderate AD were recruited and divided into memantine-sensitive AD and memantine-insensitive AD groups. For moderate AD, the logistic regression model (LRM) and the receiver operating characteristic (ROC) curve based on patients’ serum levels of VEGF, BDNF, IL-6 and IL-1β was promising for diagnosing and choosing the best course of treatment.