Brunner FJ, Waldeyer C, Ojeda F, et al. - In this risk-evaluation and risk-modeling study of data from 19 countries across Europe, Australia, and North America, experts examined the cardiovascular disease risk related to the full spectrum of bloodstream non-HDL cholesterol concentrations and created an easy-to-use tool to assess the long-term possibilities for a cardiovascular disease event correlated with non-HDL cholesterol and modeled its risk decrease by lipid-lowering treatment. Of the 524,444 people in the 44 cohorts, 398,846 people belonging to 38 cohorts were pooled and randomized into the derivation (n = 199,415) and validation cohort (n = 199,431). Non-HDL cholesterol concentrations in blood were robustly related to the long-term risk of atherosclerotic cardiovascular disease. Also, a simple tool for unique long-term risk evaluation and the possible advantage of the early lipid-lowering intervention was provided. Moreover, regarding primary prevention approaches, these data could be beneficial for physician-patient communication.