Liu X, Zhang H, Li Y, et al. - This study was conducted to evaluate the efficacy and safety of incisional negative pressure wound therapy (iNPWT) following total ankle replacement. Researchers performed a retrospective cohort study in patients who had undergone total ankle replacement between January 2010 and June 2018. Researchers evaluated infection rate, wound complication incidence, length of stay, VAS (visual analogue scale), AOFAS (American Orthopedic Foot and Ankle Society) and SF-36 (short-form 36) scales, and ankle range of motion at 1 week, 2 weeks, 1 month, 3 months, 6 months, and 12 months postoperatively. This research enrolled a total of 34 patients (n=13 iNPWT and n=21 Control). The results of this study indicate that the use of iNPWT following total ankle arthroplasty helped reduce postoperative pain, improve ankle function, and improve patient quality of life. Nevertheless, these advantages were no longer statistically significant three months to one year after surgery.