Sebastiani G, Cocciolillo S, Mazzola G, et al. - In view of the current guidelines recommending the use of a diagnostic algorithm to evaluate disease severity in cases of suspected nonalcoholic fatty liver disease (NAFLD), researchers implemented this algorithm to HIV-monoinfected patients. Three prospective screening programs for NAFLD conducted in the following cohorts were analyzed: the Liver Disease in HIV cohort in Montreal, the Modena HIV Metabolic Clinic cohort and the Liver Pathologies in HIV in Palermo cohort. For this study, participants comprised 1,534 HIV-infected adults without significant alcohol intake or viral hepatitis coinfection. They observed the presence of the metabolic comorbidities (obesity and/or diabetes) required for entry in the diagnostic algorithm in 313 (20.4%) of these patients. According to current guidelines, detailed assessment for NAFLD and disease severity is required in one in five HIV-monoinfected patients. Moreover, referral to hepatology is required in one in ten of these patients. These findings suggest that consideration could be given to the expansion of the algorithm to patients with any metabolic comorbidities.