Vasunilashorn SM, Ngo LH, Inouye SK, et al. - Since apolipoprotein E (APOE) status can modify the risk of postoperative delirium conferred by inflammation, researchers ascertained if APOE modifies the established connection between C-reactive protein (CRP) and delirium incidence, severity, and duration among 553 noncardiac surgical individuals aged 70 and older. Data reported that the prevalence of the APOE ε4 carrier was 19% and the postoperative delirium was 24%. The incidence, severity, and duration of the connection between CRP and delirium varied by the status of ε4. There was a strong link between high CRP (compared with low CRP) and delirium incidence among ε4 carriers. There was, however, no significant interaction among non-ε4 carriers. Findings suggested that the association between postoperative day 2 CRP levels and postoperative delirium can be affected by the APOE ε4 carrier status.