Cao J, Nomura SO, Steffen BT, et al. - Using a subpopulation of the Multi-Ethnic Study of Atherosclerosis cohort, researchers explored if discordance between apolipoprotein B (apo B) and low-density lipoprotein cholesterol (LDL-C) or non-high-density lipoprotein cholesterol (non-HDL-C) levels was related to subclinical atherosclerotic cardiovascular disease (ASCVD) measured by coronary artery calcium (CAC). The study sample aged 45 to 84 years, was free of ASCVD, and not receiving lipid-lowering medications at baseline (2000-2002). Among adults ≥ 45 years not on statins, Apo B was found to be related to CAC, but offered only modest additional predictive worth of apo B for CAC prevalence, incidence or progression beyond LDL-C or non-HDL-C. For ASCVD risk evaluation, Apo B discordance may still be significant.