Chen TK, et al. - This study was performed to ascertain whether the APOL1 risk variants are related to incident proteinuria in the context of hypertension-attributed CKD and whether subsequent kidney function decline after the onset of proteinuria differs by APOL1 risk status. Among blacks with established moderate CKD, the APOL1 high-risk variants are related to greater risk of incident proteinuria. After proteinuria onset, kidney function declines more rapidly but does not differ by APOL1 risk status. This recommends that factors that lead to proteinuria, beyond APOL1, may additionally drive CKD progression.