Zheng KH, Arsenault BJ, Kaiser Y, et al. - Given that apolipoprotein B/apolipoprotein A-I (apoB/apoA-I) ratio and lipoprotein(a) (Lp[a]) are related to aortic valve stenosis (AVS) disease progression but the impacts of clinical features such as age, sex, and presence of concomitant coronary artery disease, on these links have not been properly described in longitudinal investigations, therefore, researchers evaluated these links between apoB/apoA-I ratio, Lp(a), and AVS incidence in a large population study, named as the European Prospective Investigation Into Cancer in Norfolk Prospective Population Study. They analyzed data from 17,745 participants (mean age, 59.2±9.1 years; men, 44.9%). Findings revealed a link between apoB/apoA-I ratio and risk of AVS incidence, this was particularly seen in younger and female participants and those without concomitant coronary artery disease. An independent risk for AVS incidence was conferred by Lp(a).