Gao YH, et al. – In this cross–sectional study, the rate, risk factors, association with disease severity and impact of anxiety and depression on health–related quality of life (HRQoL) were investigated in adult outpatients with steady–state bronchiectasis. The findings suggested that anxiety and depression were common in bronchiectasis and can negatively affect HRQoL, but not related to disease severity. In addition, prompt assessment and treatment of these mental disorders, regardless of bronchiectasis severity, are advocated and might improve HRQoL.

Methods

• One hundred sixty-three outpatients (102 females; mean age, 45.8 years) and eighty healthy subjects (47 females; mean age, 47.1 years) were included in this cross-sectional study.
• Demographic, clinical indices, radiology, spirometry, aetiology, sputum bacteriology, Hospital Anxiety and Depression Scales (HADS), Pittsburgh Sleep Quality Index (PSQI), and St. George's Respiratory Questionnaire (SGRQ) were evaluated.

Results

• The results of this study showed that patients with steady-state bronchiectasis had a higher rate of depression (HADS-depression >7) (30.1% v.s. 10.0%, P=0.001) and anxiety (HADS-anxiety >7) (39.9% v.s. 6.3%, P<0.001) compared with healthy subjects.
• No significant differences in the rate of anxiety and depression were observed across different disease severity, evaluated with BSI and FACED score (all P>0.05).
• In multivariate model, factors related to anxiety included younger age (OR=1.05), education below college graduate (OR=4.55), and sleep disturbance (PSQI≥6) (OR=2.95); whereas sleep disturbance was the sole factor correlated with depression (OR=5.98).
• It was observed in the findings that patients with either depression or anxiety had more markedly impaired HRQoL affecting most domains than those without.