Antiviral therapy for hepatitis B prevents liver injury in patients with tuberculosis and hepatitis B coinfection
Clinical Infectious Diseases Feb 09, 2020
Lui GCY, Wong NS, Wong RYK, et al. - In view of the observation that the risk of liver injury increases in correlation with chronic hepatitis B virus (HBV) infection among patients who undergo antituberculosis treatment, researchers here examined whether antiviral treatment for HBV at the time of tuberculosis diagnosis would reduce the risk of liver injury. They performed a population-level, retrospective, cohort study including 3,698 patients with tuberculosis–HBV coinfection who underwent treatment in public hospitals in Hong Kong over a 16-year period. Among these patients, 488 (13.2%) were on antiviral therapy. Outcomes suggest that the risk of liver injury reduces in correlation to receiving antiviral treatment for HBV at the time of tuberculosis diagnosis in tuberculosis–HBV coinfected patients. Compared with patients who initiated antiviral treatment within 1 year of tuberculosis diagnosis, patients on antiviral treatment also had a lower risk of hospitalization due to drug-induced liver injury and a lower risk of liver-related mortality.
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