Byrd KK, Hou JG, Hazen R, et al. - Given that for HIV viral suppression, a benchmark of near-perfect adherence (≥ 95%) to antiretroviral therapy (ART) is often cited as necessary, however, with the emergence of newer, more effective ART medications, a lower threshold for viral suppression is expected. Hence researchers sought to determine the minimum ART adherence level necessary to achieve viral suppression. In the setting of the Patient-centered HIV Care Model demonstration project, they determined adherence to ART relating the proportion of days covered measure for the 365-day period before each viral load test result, and grouped these into five categories (< 50%, 50% to < 80%, 80% to < 85%, 85% to < 90%, and ≥ 90%). Observations revealed no differences in the adjusted odds of viral suppression between persons with an adherence level of 80% to < 85% or 85% to < 90% and those with an adherence level of ≥ 90%. In addition, the overall estimated adherence level necessary to achieve viral suppression was 82% in 90% of viral load tests; further, there was variation in estimated adherence level by regimen type. With adherence levels of 75% and 78%, integrase inhibitor- and nonnucleoside reverse transcriptase inhibitor-based regimens led to achievement of 90% viral suppression, respectively. These findings thereby suggest the possibility of requiring lower ART adherence levels to reach HIV viral suppression than previously thought and their dependence on the regimen used.