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Antiphospholipid antibodies in adult IgA vasculitis: Observational study

Clinical Rheumatology Aug 06, 2018

Hocevar A, et al. - Authors assessed the occurrence of antiphospholipid antibodies (aPLs) in acute adult IgA vasculitis (IgAV) and assessed their potential correlations with IgAV clinical presentation. At their secondary/tertiary rheumatology center, experts determined lupus anticoagulants (LAs) and IgG, IgM, and IgA isotypes of anticardiolipin antibodies (aCL), antibodies against β2-glycoprotein I (aβ2GPI) and against the phosphatidylserine-prothrombin complex (aPS/PT) in prospectively collected, histologically proven IgAV, diagnosed for the first time between January 2013 and February 2018. In acute diseases, renal involvement was more commonly seen in the subset of IgA aPS/PT-positive patients. During acute IgAV episodes, aPLs were commonly detected. In comparison with the IgAV patients without aPLs, patients with aPLs have similar clinical presentation, but higher markers of inflammation. Renal involvement was more commonly seen in the subset of IgAV patients with IgA aPS/PT.

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