Singh N, et al. - Because antioxidants (AO) supplementation was evaluated for pain in chronic pancreatitis (CP), researchers assessed the effect of AO on endocrine function in CP. For this investigation, 107 CP patients assigned to receive daily combined AO or placebo (PL) for six months. Investigators found an increase in levels of serum selenium and serum vitamin E in the AO than the PL group. According to this double-blind placebo-controlled randomized pilot study, supplementation with AO to CP patients causes a sustained increase in AO blood levels. However, there is no additional benefit over PL on endocrine and exocrine functions, fibrosis markers, oxidative stress (OS) and inflammation, nutritional status, pain and quality of life.