Choi MY, et al. - Using the Systemic Lupus International Collaborating Clinics inception cohort, researchers investigated the prevalence of indirect immunofluorescence (IIF) anticellular antibody staining. They used baseline serum to detect anticellular antibodies by IIF on HEp-2000 substrate. Examination of three serologic subsets was done: antinuclear antibody (ANA) positive [presence of either nuclear or mixed nuclear/cytoplasmic and mitotic cell pattern (CMP) staining], anticellular antibody negative (absence of any intracellular staining), and isolated CMP staining. Among a total of 1,137 included patients, 1,049 (92.3%) were ANA positive, 71 (6.2%) were anticellular antibody negative, and 17 (1.5%) had an isolated CMP. A likely decrease in the prevalence of anticellular antibody–negative systemic lupus erythematosus is expected as emerging nomenclature guidelines recommend that non-nuclear patterns should also be reported as a positive ANA.