Lin LY, Riccobene T, Debabov D, et al. - Researchers investigated the antibacterial activity of ceftazidime-avibactam (CAZ-AVI) against bacterial isolates from children in the United States with a urinary tract infection (UTI) or intra-abdominal infection (IAI) during the 2016–2019 International Network for Optimal Resistance Monitoring program. In addition, they determined the prevalence of isolates and susceptibility to CAZ-AVI in pediatric vs adult patients. Escherichia coli (62.5%), Klebsiella pneumoniae (12.1%) and Proteus mirabilis (6.2%) were the most prevalent Enterobacterales pathogens in children with UTIs. In children with IAIs, the most prevalent Enterobacterales pathogens were E. coli (57.4%), K. pneumoniae (11.1%) and Enterobacter cloacae species complex (9.3%). Prevalence and susceptibilities exhibited by contemporary UTI and IAI pathogens collected from US children from 2016 to 2019 were similar to those exhibited by isolates collected from adult patients. Potent activity was shown by CAZ-AVI against these pathogens.