Rigamonti A, et al. - After adjusting for known prognostic factors (age, extent of surgery, Karnofsky performance status, radiochemotherapy), this retrospective study examined the impact of antiepileptic drugs (AED) therapy on overall survival (OS) in adult patients with glioblastoma multiforme (GBM). No significant variation was reported in the OS of patients receiving AED from that of patients not receiving an AED. Additionally, OS did not significantly vary between patients receiving enzyme-inducing AED or non-enzyme-inducing AED.