Guilfoyle SM, et al. - This study was performed to investigate baseline psychological functioning and antiepileptic drug (AED) behavioral side effects in new onset epilepsy. Moreover, using age, the physicians determined whether baseline psychological functioning predicted AED behavioral side effects 1 month following AED initiation. Younger children appeared to be more inclined to experience behavioral side effects. These side effects were expected to be higher if youths with epilepsy had baseline hyperactivity/impulsivity. Baseline psychological screening could be used as a precision medicine tool for AED selection, particularly hyperactivity.