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Antidepressants in breast milk; Comparative analysis of excretion ratios

Archives of Women's Mental Health Aug 22, 2018

Schoretsanitis G, et al. - Given the increasing prescription rates of antidepressants in pregnant and breastfeeding women over the past decades, researchers investigated drug exposure for neonates through lactation. Among 17 women receiving antidepressant therapy, they measured concentrations of three antidepressants citalopram, sertraline, and venlafaxine in maternal blood and breast milk during the breastfeeding period. Outcomes suggest that children are constantly exposed to measurable drug concentrations when breastfed under antidepressant treatment. As there seems no association between daily dosage and serum concentration of the antidepressants and drug concentrations in mother milk, measuring of drug concentrations in milk may assist in determining drug exposure during breastfeeding.
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