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Anticoagulation after surgical or transcatheter bioprosthetic aortic valve replacement

Journal of the American College of Cardiology Sep 02, 2019

Chakravarty T, Patel A, Kapadia S, et al. - Using pooled cohort of PARTNER2 (Placement of Aortic Transcatheter Valves) randomized trials and nonrandomized registries, researchers investigated how valve hemodynamics and clinical outcomes of patients undergoing bioprosthetic aortic valve replacement (AVR) (n = 4,832) could be influenced by anticoagulation (AC) after the procedure. They gathered data on antiplatelet and antithrombotic therapy. At 30 days and 1-year after AVR, echocardiograms were performed. No adverse clinical events, no significant influence on aortic valve hemodynamics (aortic valve gradients or area) and reduced rates of stroke following surgical AVR (but not post-transcatheter aortic valve replacement) were reported in correlation with early AC after bioprosthetic AVR, in the short term. It is still to be examined if early AC after bioprosthetic AVR has an influence on long-term outcomes.
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