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Anticholinergic drug exposure and the risk of dementia: A nested case-control study

JAMA Aug 09, 2019

Coupland CAC, et al. - Researchers undertook this nested case-control study involving 58,769 patients with dementia and 225,574 matched controls in order to assess how different types of anticholinergic medication are associated with the risk of dementia among persons 55 years or older. They found that exposures to anticholinergic antidepressants, anti-Parkinson drugs, antipsychotic drugs, bladder antimuscarinics, and antiepileptic drugs were statistically significantly correlated with dementia risk after adjusting for confounding variables. Findings emphasized practicing caution when prescribing these drugs in middle-aged and older adults.

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