Chiesa-Estomba CM, et al. - Since 2016, antibiotic prophylaxis has not been used in the department for benign clean head and neck surgery, researchers explored the impacts of prophylactic antibiotic administration on benign masses in clean head and neck surgery, analyzing retrospective information from an Otorhinolaryngology–Head & Neck Surgery Department in a Tertiary University Hospital. Participants in the study were 204 patients. According to this observational retrospective cohort study, it is not essential to use prophylactic antibiotics in clean, benign head and neck surgery. However, doctors and surgeons should be conscious of the possibility of developing serious or even fatal surgical site infections, and it needs to be explained to the patient prior to any surgery.