Li WC, et al. - In this study, researchers assessed to estimate the association of the antiarrhythmic effect of additive sevoflurane to histidine-tryptophan-ketoglutarate (HTK) solution with connexin 43 (Cx43) protein. They assessed the total Cx43 level and the phosphorylation of Cx43 at Ser368 (Cx43-pS368) by Western blotting and the distribution of Cx43 by immunohistochemistry. They observed a relative increment of total Cx43 and Cx43-pS368 levels in Sevo-HTK solution. They noted no changes in transmural repolarization dispersion (TDR) with prevention of Cx43 redistribution and decreasing conduction velocity (CV). Although, they noticed shorter graft re-beating times, improvement in myocardial pathological damage as well as a reduction in number of apoptotic cells. They concluded a relation of decline in hypothermia and ischemia-induced reperfusion arrhythmias with Sevo-HTK solution to the phosphorylation of Cx43 at serine 368.