Osaka R, et al. - This work was undertaken to compare the 12-month efficacy of 1 initial intravitreal injection of an anti-vascular endothelial growth factor (VEGF) agent followed by pro re nata (PRN) dosing with that of 3 initial monthly injections followed by PRN dosing in patients with macular edema (ME) after central retinal vein occlusion (CRVO). Researchers observed that 1 initial injection regimen achieved 12-month outcomes similar to those of a 3 monthly injections regimen with fewer injections when used for ME after CRVO.