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Anti-TNF therapy is associated with decreased imaging and radiation exposure in patients with Crohn's disease

Inflammatory Bowel Disease Oct 18, 2019

Patil SA, et al. - In this retrospective review, researchers compared the effective dose of radiation in Crohn's disease (CD) patients the year prior to and the year after initiation of anti-tumor necrosis factor (anti-TNF) agents or corticosteroids. Between 2004 and 2009, they included 99 CD individuals started on anti-TNF therapy or corticosteroids in a tertiary care center. According to results, 65 individuals were started on anti-TNF agents and 34 were initiated on corticosteroids. Compared with the corticosteroid group, the anti-TNF group had significantly more stricturing, penetrating, and perianal disease. Anti-TNF therapy initiation for CD treatment is linked to a significant reduction in exposure to diagnostic radiation. On the other hand, treatment with steroids does not reduce exposure to diagnostic radiation.
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