Boso F, et al. – This research was designed to evaluate whether the combination of sulfatide with galactocerebroside would increase sensitivity or specificity of enzyme–linked immunosorbent assay testing compared to sulfatide alone. Compared to anti–sulfatide antibodies alone, testing for both sulfatide and galactocerebroside in immunoglobulin M (IgM) paraproteinemic neuropathies seemed to increase the sensitivity (49% and 39%, respectively, with a slightly reduced specificity, from 97% to 87%), helping the characterization of otherwise undefined neuropathy that could benefit from immunomodulatory therapy.