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Anti-Müllerian hormone variability and its implications for the number of oocytes retrieved following individualized dosing with follitropin delta

Clinical Endocrinology Mar 22, 2019

Nelson SM, et al. - In this retrospective analysis of repeat anti-Müllerian hormone (AMH) measures from a randomized controlled trial involving 1,326 women (aged 18-40 years), investigators examined the inter- and intra-cycle variability in repeated measurements and evaluated the impact on an individualized gonadotropin dosing algorithm and predicted oocyte yield. Findings revealed that repeat serum AMH measurements within individual women have been strongly correlated. According to the findings obtained, AMH variability had restricted effect on individualized dosing of gonadotropin; 95% of women forecast oocyte yields that do not vary beyond 1 oocyte count, regardless of whether a random or early follicular AMH measurement was used to determine the individualized dose of gonadotropin.

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