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Anti-Müllerian hormone variability and its implications for the number of oocytes retrieved following individualized dosing with follitropin delta

Clinical Endocrinology Feb 27, 2019

Nelson SM, et al. - In this retrospective analysis of repeat anti-Müllerian hormone (AMH) measures from a randomized controlled trial involving 1326 women (aged 18-40 years), researchers analyzed the inter- and intra-cycle variability in repeated measurements and evaluated the impact on an individualized gonadotropin dosing algorithm and predicted oocyte yield. In individual women, repeated serum AMH measurements were strongly correlated. According to the findings obtained, the variability of AMH had a limited impact on the individualized dosage of gonadotropin, with 95% of women predicted to obtain an oocyte yield that does not exceed 1 oocyte count, regardless of whether the individualized dose of gonadotropin was determined by a random or early follicular AMH measurement.
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