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Anti-müllerian hormone and ovarian reserve: Update on assessing ovarian function

Journal of Clinical Endocrinology and Metabolism Aug 12, 2020

Moolhuijsen LME, et al. - Granulosa cells of small growing follicles in the ovary produce anti-Müllerian hormone. Studies have established a strong correlation of serum AMH levels with the number of growing follicles, and hence, these levels are suggested to have utility as a marker for ovarian reserve. Via this review, researchers sought to report on recent findings and limitations in the application of serum AMH in ovarian reserve assessment. A PubMed search was made to assess the recent literature on the measurements and use of serum AMH as a marker for ovarian reserve. Per data gained, serum AMH is still the preferred ovarian reserve marker. However, there is lack of an international standard for AMH which prevents comparison between AMH assays. Furthermore, knowledge concerning endogenous and exogenous factors that influence serum AMH levels is limited, which prevents proper interpretation of AMH values in a clinical setting.

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