Tsuji H, Ohmura K, Jin H, et al. - This study sought to evaluate whether DNA binds to HLA class II molecules in a manner similar to that of misfolded proteins and whether DNA bound to HLA class II molecules is involved in systemic lupus erythematosus (SLE) pathogenicity. Researchers examined the binding of DNA to HLA class II molecules, as well as the response of cells expressing anti-DNA B cell receptors (BCR) to cells expressing the DNA/HLA class II complex. In SLE pathogenesis, DNA bound to HLA class II molecules is involved.