Shepherd E, Salam RA, Manhas D, et al. - Researchers performed a systematic review and meta-analysis to assess whether antenatal magnesium sulphate is correlated with unintended adverse neonatal outcomes. They searched CINAHL, Cochrane Library, LILACS, MEDLINE, Embase, TOXLINE, and Web of Science for the database (inceptions to 3 September 2019). Randomized, quasi-randomized, and non-randomized trials, cohort and case-control studies, and case reports evaluating antenatal magnesium sulphate for pre-eclampsia, eclampsia, fetal neuroprotection, or tocolysis, in comparison with placebo/no treatment or a different magnesium sulphate regimen, were involved. These findings do not establish a clear correlation between antenatal magnesium sulphate for useful indications and adverse neonatal outcomes. Further large, high-quality studies (prospective cohorts or individual participant data meta-analyses) assessing specific outcomes, or the effect of regimen, pregnancy, or birth characteristics on these results, would future inform safety recommendations.