Otsuka K, et al. - Among 104 end-stage kidney disease (ESKD) patients treated with maintenance hemodialysis, researchers investigated if ankle-brachial index (ABI)/brachial-ankle pulse wave velocity would offer better prognostic value independent of biomarkers. Participants were followed for a mean duration of 3.6 ± 1.7 years. Age >75 years, abnormal ABI, left ventricular ejection fraction <50%, the upper tertile of high-sensitive cardiac troponin T and high-sensitive C-reactive protein were identified as independent factors related to major adverse cardiovascular event (MACE). Independent of biomarkers, abnormal ABI was identified as a robust predictor of MACE. In ESKD patients, better risk stratification was achieved with the combination of predictors vs a single predictor.