Lyu J, et al. - Given that in pancreatic beta cells, ATP-binding cassette transporter A1 (ABCA1), a 254-kDa membrane protein, affects cholesterol homeostasis and insulin secretion, and angiotensin II decreases glucose-stimulated insulin secretion (GSIS), researchers assessed the impact of angiotensin II on ABCA1 expression in primary pancreatic islets and INS-1 cells. They found that ABCA1 expression was suppressed by angiotensin II in pancreatic islets and INS-1 cells. This suggests a possible impact of angiotensin II on GSIS via regulating ABCA1 expression.