Reed GW, et al. - In this observational study, researchers looked for angiographic features can predict long-term outcomes for patients with radiation-associated coronary artery disease (CAD) treated with percutaneous coronary intervention (PCI). Participants were 157 patients with malignancy who received radiation therapy (XRT) prior to PCI. They compared rates of major adverse cardiovascular and cerebrovascular events (MACCEs; all-cause mortality, myocardial infarction, repeat revascularization, or stroke) across patient characteristics over time. Patients with at least moderate target vessel calcification, ostial stenosis, target vessel diameter ≥ 3.0 mm, a SYNTAX score ≥ the median of 11, or bare metal stenting (BMS)/balloon angioplasty (BA) were found to experience a more frequent occurrence of MACCE vs drug-eluting stenting (DES), as seen via Kaplan–Meier's analysis of angiographic characteristics. In patients with SYNTAX score ≥ 11 or BMS, cardiac death was more frequently seen. BMS placement, chronic kidney disease ≥ stage 3, New York Heart Association (NYHA) heart failure class ≥3, and SYNTAX score ≥ 11 were identified as independent predictors of MACCE following multivariable adjustment for both angiographic and clinical characteristics.