Martazanova B, Mishieva N, Vtorushina V, et al. - In view of the association of interleukin 8 (IL‐8), vascular endothelial growth factor A (VEGFA), its receptors 1 (VEGFR1) and 2 (VEGFR2) with ovarian hyperstimulation syndrome (OHSS) pathophysiological mechanisms, researchers here investigated the concentrations of these cytokines depending on the way of ovulation triggering. In the IVF program, 51 high‐responder patients were included. The patients received gonadotropin‐releasing hormone agonists (GnRHa) trigger + 1500 IU human chorionic gonadotropin (hCG) support on the oocyte pick‐up (OPU) day (group I), dual trigger (GnRHa + 1500 IU hCG; group II), or hCG trigger 10000 IU (group III) for the final oocyte maturation. Findings suggest that a small dose of hCG induces concentrations of VEGFA similar to a full dose of hCG, however, GnRHa triggering decreased the concentrations of VEGFR2, which could result in the OHSS prevention.